Bioprocess Engineering of Reactions,

Edition 4

Editors: By Shijie Liu

Publication Date: 01 Jun 2026

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Bioprocess Engineering of Reactions, Fourth Edition is a systematic and comprehensive resource that explores principles and analysis of reactions within the bioprocess and biotechnology industries. The book provides a step-by-step guide to understanding batch, continuous, and fed-batch reactor operations, reflecting the growth behavior of cells through various phases. It introduces innovative pinch methods for optimizing batch reactors without relying on complex mathematical models while also addressing the intricacies of enzymatic systems and the impact of phase separation on reaction dynamics. Topics covered include biomolecular reaction basics, ideal flow reactors, batch fermentation, continuous culture, and the engineering of cells.

Other sections emphasize sustainability and stability in bioprocess operations while discussing critical factors such as reactivity hazards and biohazards. With a focus on mass and heat transfer, reactor design, and real reactor deviations, the book equips readers with the knowledge to navigate the complexities of bioprocess engineering. It will be an invaluable resource for bioprocess engineers, researchers, and students in in biotechnology, chemical engineering, and molecular biology. By linking reactor operations to specific cell growth patterns and providing insights into optimization strategies, the book also empowers professionals to enhance productivity and ensure safety in their bioprocess endeavors.

Key Features

Facilitates easy understanding of complex bioprocess operations by linking various modes of reactor operations to specific batch cell growth patterns
Applies pinch methods and techniques to batch cultivation processes, providing insights into kinetic complexities
Explores the implementation of fed-batch strategies to optimize bioprocess operations
Evaluates critical factors such as sustainability, reactivity hazards, and biohazards, offering comprehensive guidance on managing these key aspects within the bioprocess industry

About the author

By Shijie Liu, Professor and Director of Bioprocess Engineering, State University of New York, NY, USA

1. Introduction
2. Biomolecular Reaction Basics
3. Batch Reactor
4. Ideal Flow Reactors
5. Enzymatic Reaction Engineering
6. Batch Fermentation
7. Continuous Culture
8. Semibatch Cultivation
9. Engineering of Cells
10. Sustainability and Stability
11. Combustion, Reactive Hazard and Bioprocess Safety
12. Mass Transfer Effects: Immobilized and Heterogeneous Reaction Systems
13. Real Reactors and Residence Time Distributions
14. Bioreactor Design & Operation

ISBN: 9780443456213

Page Count: 730

Retail Price :

(Under)graduate students in bioengineering, bioprocess engineering, chemical engineering, and biological engineering