Pathophysiology,

Edition 8

Editors: By Jacquelyn L. Banasik, PhD, ARNP

Publication Date: 16 Jan 2026

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Gain the in-depth understanding of pathophysiology you need to guide your patient care! Using a systems approach, Pathophysiology, 8th Edition, examines the etiology, pathogenesis, clinical manifestations, and treatment of diseases and disorders. The book begins with a review of normal anatomy and physiology, followed by pathophysiology and application of concepts to specific disorders. Each chapter includes a discussion of the disease processes and abnormalities that may occur, with a focus on the pathophysiologic concepts involved. Written by a team of expert contributors led by Jacquelyn Banasik, this text emphasizes the major pathophysiology concepts relevant to clinical practice while not overwhelming the reader with minute detail.

Key Features

Clear, easy-to-read writing style emphasizes critical thinking, and includes many tables, boxes, and figures to highlight key content
Thorough updates include information on the newest scientific findings and advances in treatment, more than 100 new figures for improved clarity, and more
More than 1,000 full-color photos and illustrations help to clarify complex pathophysiological concepts
Global Health Care boxes summarize topics such as COVID-19, HIV/AIDS, Ebola, tropical diseases, and more, with information on prevalence, mechanism of disease and transmission
Pediatric and Older Adult Considerations boxes address age-related changes associated with specific body systems
Useful learning resources include chapter outlines, bolded key terms, key questions, Key Points boxes, Clinical Judgment challenges, and chapter summaries

New Features

NEW! Updated content throughout the book reflects the latest research and thinking in pathophysiology

About the author

By Jacquelyn L. Banasik, PhD, ARNP, Associate Professor, WSU Intercollegiate College of Nursing, Washington State University, Spokane, WA, USA

UNIT I Pathophysiologic Processes
1 Introduction to Pathophysiology
Framework for Pathophysiology
Concepts of Normality in Health and Disease
Epidemiology

2 Homeostasis Allostasis and Adaptive Responses to Stressors
Homeostasis and Allostasis
Stress as a Concept
Neurohormonal Mediators of Stress and Adaptation
Adaptation Coping and Illness

UNIT II Cellular Function
3 Cell Structure and Function
Plasma Membrane
Organization of Cellular Compartments
Cellular Metabolism
Functions of the Plasma Membrane
Intercellular Communication and Growth

4 Cell Injury Aging and Death
Reversible Cell Injury
Cellular Adaptation
Irreversible Cell Injury
Etiology of Cellular Injury
Aging
Somatic Death

5 Genome Structure Regulation and Tissue Differentiation
Structure and Function of Deoxyribonucleic Acid
Regulation of the Genome
Differentiation of Tissues

6 Genetic and Developmental Disorders
Principles of Inheritance
Genetic Disorders
Chromosomal Abnormalities
Mendelian Single-Gene Disorders
Nonmendelian Single-Gene Disorders
Polygenic and Multifactorial Disorders
Environmentally Induced Congenital Disorders
Diagnosis Counseling and Gene Therapy

7 Neoplasia
Benign Versus Malignant Growth
Epidemiology and Cancer Risk Factors
Genetic Mechanisms of Cancer
Multistep Nature of Carcinogenesis
Invasion and Metastasis
Effects of Cancer On the Body
Cancer Therapy

UNIT III Defense
8 Infectious Processes
Host-Microbe Relationship
Transmission of Infection
Types of Pathogenic Organisms

9 Inflammation and Immunity
Components of the Immune System
Epithelial Barriers
Mononuclear Phagocyte System
Lymphoid System
Leukocytes
Chemical Mediators of Immune Function
Innate Defenses and Inflammation
Inflammation
Healing
Inflammatory Exudates
Systemic Manifestations of Inflammation
Specific Adaptive Immunity
Major Histocompatibility Complex
Antigen Presentation By Major Histocompatibility Complex
Mechanisms of Cell-Mediated Immunity
Mechanisms of Humoral Immunity
Antibody Structure
Passive and Active Immunity
Integrated Function and Regulation of the Immune System
Integrated Response to Microbial Antigen
Integrated Response to Viral Antigen
Regulation of Immune Function

10 Alterations in Immune Function
Excessive Immune Responses
Autoimmunity
Hypersensitivity
Deficient Immune Responses
Primary Immunodeficiency Disorders
Secondary Immunodeficiency Disorders

11 Malignant Disorders of White Blood Cells
Classification of Hematologic Neoplasms
Etiology of Myeloid and Lymphoid Neoplasms
General Principles of Management
Myeloid Neoplasms
Lymphoid Neoplasms

12 HIV Disease and Aids
Epidemiology
Etiology
Pathogenesis
Diagnostic Testing
Monitoring the Progression of HIV
Clinical Manifestations
Treatment

UNIT IV Oxygen Transport Blood Coagulation Blood Flow and Blood Pressure
13 Alterations in Oxygen Transport
Composition of Blood
Structure and Function of Red Blood Cells
Gas Transport and Acid-Base Balance
Anemia
Anemia Related to Decreased Red Cell Production
Anemia Related to Inherited Disorders of the Red Cell
Anemia Related to Extrinsic Red Cell Destruction or Loss
Polycythemia

14 Alterations in Hemostasis and Blood Coagulation
The Process of Hemostasis
Evaluation of Hemostasis and Coagulation
Vascular and Platelet Disorders
Coagulation Disorders

15 Alterations in Blood Flow
Organization of the Circulatory and Lymphatic Systems
Principles of Flow
Control of Flow
General Mechanisms that Cause Altered Flow
Alterations in Arterial Flow
Alterations in Venous Flow
Alterations in Lymphatic Flow

16 Alterations in Blood Pressure
Arterial Blood Pressure
Mechanisms of Blood Pressure Regulation
Hypertension
Low Blood Pressure

UNIT V Cardiac Function
17 Cardiac Function
Cardiovascular Anatomy
Cardiac Cycle
Coronary Circulation
Cardiac Myocytes
Molecular Basis of Contraction
Cardiac Energy Metabolism
Cardiac Electrophysiology
Electrocardiography
Determinants of Cardiac Output
Endocrine Function of the Heart
Tests of Cardiac Function

18 Alterations in Cardiac Function
Coronary Heart Disease
Endocardial and Valvular Diseases
Myocardial Diseases
Pericardial Diseases
Congenital Heart Diseases

19 Heart Failure and Dysrhythmias
Heart Failure
Cardiac Dysrhythmias

20 Shock
Pathogenesis of Shock
Types of Shock
Assessment and Hemodynamic Monitoring
Complications of Shock

UNIT VI Respiratory Function
21 Respiratory Function and Alterations in Gas Exchange
Functional Anatomy
Ventilation
Pulmonary Blood Flow
Diffusion and Transport of Respiratory Gases
Alterations in Pulmonary Function
Diagnostic Tests
Alterations in Pulmonary Vasculature
Pulmonary Malignancies

22 Obstructive Pulmonary Disorders
Obstruction From Conditions in the Wall of the Lumen
Obstruction Related to Loss of Lung Parenchyma
Obstruction of the Airway Lumen

23 Restrictive Pulmonary Disorders
Lung Parenchyma Disorders
Atelectatic Disorders
Pleural Space Disorders
Neuromuscular Chest Wall and Obesity Disorders
Infection or Inflammation of the Lung

UNIT VII Fluid Electrolyte and Acid-Base Homeostasis
24 Fluid and Electrolyte Homeostasis and Imbalances
Body Fluid Homeostasis
Fluid Imbalances
Principles of Electrolyte Homeostasis
Electrolyte Imbalances

25 Acid-Base Homeostasis and Imbalances
Linda Felver
Acid-Base Homeostasis
Acid-Base Imbalances

UNIT VIII Renal and Bladder Function
26 Renal Function
Renal Anatomy
Overview of Nephron Structure and Function
Regulation of Glomerular Filtration
Transport Across Renal Tubules
Regulation of Blood Volume and Osmolality
Endocrine Functions
Age-Related Changes in Renal Function
Tests of Renal Structure and Function

27 Intrarenal Disorders
Common Manifestations of Kidney Disease
Congenital Abnormalities
Neoplasms
Infection
Obstruction
Glomerular Disorders (Glomerulopathies)

28 Acute Kidney Injury and Chronic Kidney Disease
Acute Kidney Injury
Chronic Kidney Disease
Clinical Management

29 Disorders of the Lower Urinary Tract
Lower Urinary Tract
Lower Urinary Tract Symptoms and Syndromes
Neurogenic Bladder
Congenital Disorders
Neoplasms
Inflammation and Infection
Obstruction

UNIT IX Genital and Reproductive Function
30 Male Genital and Reproductive Function
Courtney Foss
Anatomy
Embryology
Male Reproductive Physiology

31 Alterations in Male Genital and Reproductive Function
Disorders of the Penis and Male Urethra
Disorders of the Scrotum and Testes
Disorders of the Prostate

32 Female Genital and Reproductive Function
Reproductive Structures
Menstrual Cycle
Breast
Pregnancy
Menopause

33 Alterations in Female Genital and Reproductive Function
Menstrual Disorders
Alterations in Uterine Position and Pelvic Support
Inflammation and Infection of the Female Reproductive Tract
Benign Growths and Aberrant Tissue of the Female Reproductive Tract
Cancer of the Female Genital Structures
Disorders of Pregnancy
Disorders of the Breast

34 Sexually Transmitted Infections
Urethritis Cervicitis Salpingitis and Pelvic Inflammatory Disease
Diseases With Systemic Involvement
Diseases With Localized Lesions
Enteric Infections

UNIT X Gastrointestinal Function
35 Gastrointestinal Function
Structure and Organization of the Gastrointestinal Tract
Gastrointestinal Motility
Secretory Function
Digestion and Absorption
Gastrointestinal Function Across the Life Span

36 Gastrointestinal Disorders
Manifestations of Gastrointestinal Tract Disorders
Disorders of the Mouth and Esophagus
Oral Infections
Esophageal Disorders
Alterations in the Integrity of the Gastrointestinal Tract Wall
Inflammation of the Stomach and Intestines
Inflammatory Bowel Disease
Enterocolitis
Alterations in Motility and Malabsorption of the Gastrointestinal Tract
Motility Disorders
Mucosal Malabsorption Disorders
Malabsorption Disorders After Surgical Intervention
Neoplasms of the Gastrointestinal Tract
Esophageal Gastric and Small Intestinal Cancers
Colonic Polyps and Colon Cancer
Psychosocial Aspects of Gastrointestinal Disorders

37 Alterations in Function of the Gallbladder and Exocrine Pancreas
Anatomy and Physiology of the Pancreaticobiliary System
Disorders of the Gallbladder
Disorders of the Pancreas

38 Liver Diseases
Structure and Function of the Liver
General Manifestations of Liver Disease
Disorders of the Liver
Cirrhosis
Toxic Liver Disorders
Other Structural Liver Conditions
Transplantation
Liver Diseases and Pediatric Considerations
Liver Diseases and Geriatric Considerations

UNIT XI Endocrine Function Metabolism and Nutrition
39 Endocrine Physiology and Mechanisms of Hypothalamic Pituitary Regulation
Hormone Structure and Action
Hormone Regulation
Hypothalamic-Pituitary Endocrine System
Thyroid Hormones
Steroid Hormones
Categories of Endocrine Disease

40 Disorders of Endocrine Function
Basic Concepts of Endocrine Disorders
Growth Hormone Disorders
Thyroid Hormone Disorders
Adrenocortical Hormone Disorders
Adrenal Medulla Disorder
Parathyroid Gland Disorders
Antidiuretic Hormone Disorders

41 Diabetes Mellitus
Regulation of Glucose Metabolism
Glucose Intolerance Disorders
Clinical Manifestations and Complications
Treatment and Education
Pediatric Considerations
Geriatric Considerations

42 Alterations in Metabolism and Nutrition
Metabolic Processes
Nutrient Metabolism
Regulation of Appetite and Nutrient Metabolism
Obesity and Metabolic Syndrome
Metabolic Responses to Starvation and Physiologic Stress
Nutritional Considerations for Aging and Altered Health States

UNIT XII Neural Function
43 Structure and Function of the Nervous System
Structural Organization
Central Nervous System
Peripheral Nervous System
Autonomic Nervous System
Neuronal Structure and Function
Neurons and Supportive Cells
Neuronal Communication
Neural Development Aging and Injury
Sensory Function
Sensory Receptors
Sensory Pathways
Somatosensory Cortex
Motor Function
Motor Neurons
Spinal Reflexes
Central Control of Motor Function
Consciousness Memory and Sleep
Consciousness and Memory
Sleep

44 Acute Disorders of Brain Function
Mechanisms of Brain Injury
Manifestations of Brain Injury
Traumatic Brain Injury
Epidemiology
Types of Traumatic Brain Injury
Primary Injury
Secondary Injury
Treatment
Cerebrovascular Disease and Stroke
Epidemiology
Ischemic Stroke
Hemorrhagic Stroke
Treatment
Stroke Sequelae
Cerebral Aneurysm and Arteriovenous Malformation
Cerebral Aneurysms
Arteriovenous Malformation
Central Nervous System Infections
Meningitis
Encephalitis
Brain Abscess

45 Chronic Disorders of Neurologic Function
Brain and Cerebellar Disorders
Spinal Cord and Peripheral Nerve Disorders

46 Alterations in Special Sensory Function
Hearing and Balance
Structure and Function of the Ear
General Manifestations of Hearing Impairment
Hearing Impairment Disorders
Otitis Media
Interventions for Individuals With Hearing Impairment
Vision
Structure of the Eye
Visual Pathways
General Manifestations of Visual Impairment
Disorders of the Eye
Interventions for Individuals With Vision Impairment
Smell and Taste
Disorders of Smell and Taste

47 Pain
Physiology of Pain
Types of Pain
Acute Pain
Chronic Pain
Cancer-Related Pain
Neuropathic Pain
Ischemic Pain
Referred Pain
Physiologic Responses to Pain
Pain in the Young and the Elderly
Treatment Modalities
Pharmacologic and Nonpharmacologic Pain Management

UNIT XIII Neuropsychological Function
48 Mental Health Disorders
Neurobiology of Psychiatric Disorders
Common Psychiatric Disorders

UNIT XIV Musculoskeletal Support and Movement
49 Structure and Function of the Musculoskeletal System
Structure and Function of Bone
Structure and Function of Joints
Structure and Function of Articular Cartilage
Structure and Function of Tendons and Ligaments
Structure and Function of Skeletal Muscle
Mechanics of Muscle Contraction

50 Alterations in Musculoskeletal Function Trauma Infection and Disease
Soft Tissue Injuries
Inert Soft Tissue Injuries
Contractile Soft Tissue Injuries
Bone Injuries and Infections
Bone and Joint Trauma
Infections of the Bone
Alterations in Bone Structure and Mass
Bone Structure Disorders
Metabolic Bone Diseases
Bone Tumors
Diseases of Skeletal Muscle
Idiopathic Inflammatory Myopathy
Muscular Dystrophy
Other Disorders of Muscle
Myasthenia Gravis
Chronic Muscle Pain

51 Alterations in Musculoskeletal Function Rheumatic Disorders
Local Disorders of Joint Function
Systemic Disorders of Joint Function
Joint Dysfunction Secondary to Other Diseases
Pediatric Joint Disorders

UNIT XV Integumentary System
52 Alterations in the Integumentary System
Age-Related Changes
Evaluation of the Integumentary System
Selected Skin Disorders
Infectious Processes
Inflammatory Conditions
Allergic Skin Responses
Parasitic Infestations
Other Disorders of the Dermis
Special Characteristics of Dark Skin
Integumentary Manifestations of Systemic Disease
Treatment Implications
Developmental Considerations

53 Burn Injuries
Thermal Injury
Electrical Injury
Chemical Injury
Special Populations

Index

ISBN: 9780443125232

Page Count: 1200

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